Herbal Remedy. How Can I Make Melting Chocolate With Cocoa Powder? Estrogen Dominance can cause all kinds of hormone symptoms including breast or ovarian fibroids, varicose veins, heavy menstrual bleeding, body fat and cellulite, fluid retention, PMS, and anxiety. May Cause Allergic Reactions 3. Preclinical studies with milk thistle extracts are showing tremendous promise in doing just that. Bosch-Barrera J, Menendez JA. Estrogen Dominance can be caused by many lifestyle factors including stress, poor diet, some meds, inadequate liver function and exposure to an estrogenic c… Always talk to your doctor before taking any herbal supplement that could have an unbalancing effect on your hormone levels. The typical dosage for silybin phytosome is 80 to 120 mg two to three times daily between meals. Phytother Res. Might Cause Abdominal Issues 2. Again, milk thistle extract is extremely well tolerated and is free of significant side effects. This helps a lot to increase the breast size as various hormones, especially estrogen are processed by the liver. These sorts of early studies have to be interpreted with great caution as they can produce misleading results because of dosage, metabolism, and concentration as well as the strain of rodent used. Ramasamy K, Agarwal R. Multitargeted therapy of cancer by silymarin. A 2016 … On the show I discussed the failure of conventional medicine to address the underlying issues in many health conditions offering little more than drugs as biochemical “band aids.”. The dosages used are simply not possible to achieve in humans taking milk thistle extract (e.g., female rates were given a daily dose of 2,750 mg of milk thistle extract per 2.2 pounds body weight). Natl Toxicol Program Tech Rep Ser. Liver support for estrogen clearance Nutritional compounds to improve Phase I and II liver detoxification include molybdenum chelate, milk thistle extract seed, dandelion root, gotu kola nut, panax ginseng, L-glutathione, glycine, N-acetyl-L-cysteine, and DL-methionine. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. Milk thistle extracts (usually standardized to contain 70-80 percent silymarin) have been shown to exert positive effects in promoting improved liver health in double-blind, clinical trials in humans. This study administered milk thistle extracts at varying dosages to different strains of mice and rats for periods up to two years, the human equivalent of lifelong exposure. Taken in appropriate doses, oral use of milk thistle appears to be safe.Milk thistle can cause: 1. Milk thistle - Supports the liver while helping to clear excess estrogen. The force of this vital pump pushes blood, carrying its payload of oxygen and nutrients, to every one of your tissues and organs and the cells that comprise them. 2011 May;(565):1-177. Additionally, methyl-folate supplements to support the methylation pathways of the liver, and liver herbs such as milk thistle and dandelion all help with general liver support. While these effects have yet to be proven in clinical studies in humans, they do show a positive effect with milk thistle consistent with dietary sources of phytoestrogens. There is simply a misguided warning. *It’s best to work with a holistic practitioner before taking herbs or supplements to suggest a plan specific to your body & needs. Milk Thistle. Every second of every minute of your life, your heart is going to beat. As a result, hormone-sensitive conditions such as breast cancer, uterine cancer, endometriosis or uterine fibroids may be worsened. 2010 Oct;24(10):1423-32. A Web Experience brought to you by LEAFtv, The University of Maryland Medical Center; Milk Thistle; Steven Ehrlich; March 2009. While these amounts appear to be sufficient in helping our cells carry out their basic functions, research indicates that boosting PQQ through supplementation can produce some amazing effects. According to the University of Maryland Medical Center, milk thistle is a traditional herbal remedy that... Mimicing Estrogen. It can help prevent elevation of liver enzymes, which can be a side effect of the medication. A small 2010 clinical study [17] involving 47 pre-menopausal and 49 post-menopausal women investigated the use of a health supplement which incorporated a combination of indole-3-carbinol, lignans, calcium glucarate, milk thistle, Schisandra chinesis and stinging nettle. It can also help trigger or worsen conditions such as endometriosis. The dosage for dried milk thistle seeds is 12 to 15 g daily. Mohd Fozi NF, Mazlan M, Shuid AN, Isa Naina M. Milk thistle: a future potential anti-osteoporotic and fracture healing agent. Ultimately, the blood returns to the heart, where the process repeats. Natural herbs may assist women who are going through the changes of life, particularly milk thistle. Toxicology and carcinogenesis studies of milk thistle extract (CAS No. When a woman’s estrogen levels are low (like during menopause and postmenopause), milk thistle may have a slight estrogenic effect. He is a licensed yoga and martial arts instructor whose work regularly appears in “Metabolism,” “Verve” and publications throughout the East Coast. Cancer Treat Rev. Can Cause Weakness The seeds contain silymarin, a group of compounds said to have antioxidant and anti-inflammatory effects. There is no single plant that does as much for the body as milk thistle. Milk thistle for the treatment of liver disease: a systematic review and meta-analysis. Milk thistle also helps to detoxify the liver and remove excess estrogen, which could help to prevent and relieve endometriosis. Milk thistle is commonly used as a home remedy to treat liver problems, often under the presumption that it will "detoxify" the liver. Milk thistle is a cleansing herb, used by many women going through menopause. The best results are achieved at higher dosages, that is, 210 milligrams of silymarin three times daily. Based in the Appalachian Mountains, Brian Connolly is a certified nutritionist and has been writing professionally since 2000. Can Interact With Estrogen 4. Cardiovascular diseases – heart attacks and strokes – are the leading cause of premature death in this country, accounting for more than 30% of all deaths in the United States. It was named milk thistle because of the white lines going across the green leaves. Green tea provides about the same amount per 4-oz. Supports liver health. Gastrointestinal issues 2. It would be like a woman taking 192,500 mg of milk thistle extract each day instead of the recommended 150 to 300 mg. Keep your daily intake below the recommended 450 milligrams a day, and avoid milk thistle if you are pregnant or nursing. The MedlinePlus website links the consumption of milk thistle plant extract with enhanced effects of estrogen in the body. Silymarin protects the liver by: • Acting as a direct antioxidant and free radical scavenger. What Exactly Does PQQ Do? Milk thistle (Silybum marianum) Mistletoe (Viscum album) Prickly pear/Nopal cactus (Opuntia) Red Clover (Trifolium pretense) Rhubarb (Rheum rhabarbarum) Saw Palemetto {Sabal fructus) Stinging nettle (Urtica dioica) ... Estrogen is the hormone added to fatten up livestock, and it fattens YOU. This means it may help reduce excess estrogen and xenoestrogens through detoxification. Supports the liver while helping to clear excess estrogen. PQQ may be the perfect answer to preventing or reversing age-related mental decline. 84604-20-6) in F344/N rats and B6C3F1 mice (Feed Studies). 2008;269: 352-362. Milk thistle (Silybum marianum), also called holy thistle and lady's thistle, is a common weed in California but grows throughout the world in climate zones 5 through 9.The plant has purple to red flowers and can be up to 10 feet tall. In women, the ovaries and the adrenal glands both produce testosterone, according to the website Aphrodite Women’s Health. What does the research say? Milk Thistle: contains silybin which may support phase 2 detoxification by boosting Glutathione. One of the most common uses of milk thistle is to treat liver problems. Taking milk thistle along with estrogens might decrease the effectiveness of estrogen pills. The therapeutic effect of milk thistle extracts in these disorders has been confirmed by biopsy as well as by clinical and laboratory data. Unfortunately, millions of people operate at a deficit and are at risk of dying too soon from damage to the heart and blood vessels. The function of the heart is absolutely critical to every other part of your body – including your brain. The Colors of Milk Labels & What They Mean. It also has no significant interactions with drugs. Because of its estrogen-stimulating properties, milk thistle is not recommended for individuals who have been diagnosed with certain estrogen-sensitive cancers, such as breast cancer. There is also a compound named Diiodolylmethane, or DIM, that works to improve healthy estrogen metabolism directly. Can Interact With Cholesterol Medication 5. Milk thistle is a phytoestrogen. Milk thistle has few known side effects, but can cause allergic reaction in some people. In fact, they show just the opposite—a protective effect. Healthy adults should limit their milk thistle dosage to 280 to 450 millgrams a day. Milk thistle can help to relieve the inflammation and pain caused by endometriosis. Milk thistle can also be taken with cholesterol-lowering medications, like statins. is it safe for breast cancer survivor to use silymarin supplement found in artichoke and milk thistle? If you have any condition that might be made worse by exposure to estrogen, don’t use these extracts. Interestingly, female rats demonstrated decreased breast (mammary) cancer and male rats showed decreased liver cancer with milk thistle extract. Though there are many theories as to why, its likely a complex combination of factors including everything from the food that we eat, to the increase in xenoestrogens in our products, and even glyphosate the ubiquitous Monsanto herbicide thats recently come under fire. Milk thistle can interact with some chemotherapy drugs — check with your doctor before you start taking it. • Increasing the cellular content of antioxidant compounds such as glutathione. It’s … Curr Drug Targets. Women who have taken hormone replacement or pharmaceutical drugs have livers that are far less efficient at clearing their body of toxins and because of this have health problems that they would normally not. Indinavir (Reyataz) Interaction Rating: Minor Be … This bitter herb helps in the detoxification process to remove excess estrogen naturally from the body. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and biliary disorders. Other parts of this wild plant, besides the seeds, are also edible. That is a scary warning, but is it valid? Try a tea or infusion consumed daily. These compounds, along with other flavonoids, may also inhibit cancer cells from dividing and reproducing. kiwiPQQ (short for pyrroloquinoline quinone) is a vitamin-like compound found in plant foods that shows a wide range of benefits for brain function and energy production. Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Extracts from milk thistle PLANT might act like estrogen. In men, the testes are responsible for testosterone production. Milk thistle is a great natural resource for detoxing the liver. Saller R, Brignoli R, Melzer J, et al. Are There Any Food Sources of PQQ? The effects of plant compounds often referred to as “phytoestrogens” like those in in ground flaxseeds, nuts and seeds, soy, many fruit and medicinal plants on estrogen receptors and metabolism is quite complex. For more information, please see the completely revised and updated 3rd edition of The Encyclopedia of Natural Medicine. It’s a gentle laxative that helps increase bowel movements. Each day the human heart beats about 100,000 times and pumps up to 5,000 gallons of fluid. Just as the media often creates stories on natural products that lack critical thinking and are fraught with incorrect conclusions, sometimes marketers of dietary supplements make the same mistake. Follow up studies have completely eliminated any concern. Depending on individual factors, your estrogen levels may show either a noticeable or nondetectable increase. Particularly PPQ-rich foods include parsley, green peppers, kiwi, papaya, and tofu. Milk thistle components have been shown to exert dual effects on bone health by preventing the breakdown of bone by cells known as osteoclasts while at the same time improving the building of bone by osteoblasts. As you digest the milk thistle, certain plant compounds in it begin to mimic the physiological functions of estrogen. Milk thistle is an herbal supplement sometimes recommended for certain health conditions. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. The warning is based solely upon selected initial in vitro (test tube) and animal models from several years ago. Looking at the scientific literature, the overwhelming majority of studies show positive results in breast cancer models as well as those on bone metabolism and zero estrogenic effects have been noted in clinical trials in humans. Dr. Paul Harper answered 51 years experience General Surgery Not sure: Milk thistle has been used medicinally for over 2, 000 years, most commonly for the treatment of liver and gallbladder disorders. National Toxicology Study Group. The standard dosage for a milk thistle preparation is based on its silymarin content (70–210 milligrams three times daily). A special extract of milk thistle bound to phosphatidylcholine, silybin phytosome, has been shown to be better absorbed and produce better results than regular milk thistle extract. Milk thistle components have been shown to exert dual effects on bone health by preventing the breakdown of bone by cells known as osteoclasts while at the same time improving the building of bone by osteoblasts. There is no existing evidence that milk thistle extract possesses any negative estrogenic effects in humans and the existing preclinical studies overwhelmingly shows it may have tremendous protective effects against breast cancer as well as osteoporosis. There really is not any controversy. Itchiness 3. Milk thistle might decrease the effects of estrogen pills by blocking how estrogen works in the body. One study showing 53% reduction in acne. Milk thistle is an herb that contains an antioxidant and anti-inflammatory substance called silymarin. Does Milk Thistle Increase Estrogen Levels? Am J Med 2002;113:506-15. It has also been shown to be safe and quite helpful in several types of liver disease, including hepatitis and cirrhosis. Some of the beneficial effects noted include: • Prevention of the expression of genes and enzymes pivotal in breast cancer development. How Do I Read Kellogg's Cereal Expiration Codes? “There was no evidence of carcinogenic activity.”. Even if milk thistle is mildly estrogenic, the benefits to our liver health probably outweigh those effects. Talk to your doctor before adding any milk thistle products to your daily routine. So, milk thistle extracts block the negative effects of estrogen on breast and uterine tissue, while acting in a beneficial way to improve bone health. Can Have Interactions During Breastfeeding And Pregnancy 7. PQQ is an extremely potent antioxidant that is able to carry out the role of an antioxidant in the body more than 20,000 times—which is a rare thing. • Inhibition of breast cancer cell growth and the inhibition of key pathways that cancer cells use to grow. Estrogen dominance essentially means high levels of estrogen in the body, which are not being pr… serving. For example, other antioxidants, such as vitamin C, are only able to accomplish this “cycling” process about four times. Milk thistle (Silybum marianum) is a perennial herb believed to have medicinal properties. According to the University of Maryland Medical Center, milk thistle is a traditional herbal remedy that has been used for a variety of ailments, such as problems with the liver and gall bladder. Milk thistle is often promoted for its liver-protecting effects. Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy. So, milk thistle extracts block the negative effects of estrogen on breast and uterine tissue, while acting in a beneficial way to improve bone health. Milk Thistle may also help support skin health by balancing hormones and detoxifying our body. 2013 Dec;14(14):1659-66. HeadacheIf you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. There are other studies that show silymarin is actually quite promising in both the prevention and possible therapeutic aid in breast cancer. What Is Milk Thistle? Testosterone Production. Estrogen dominance is at an all time high across the globe. In an average lifetime, the heart will beat 2.5 billion times and pump 146 million gallons of blood. An updated systematic review with meta-analysis for the clinical evidence of silymarin. For this reason, standardized extracts are preferred. That’s a lot of work! Milk thistle appears to be beneficial in estrogen metabolism when combined with other ingredients, as well. Can Green Tea Affect Liver Function Test Results? Forsch Komplementmed 2008;15:9-20. Because there estrogenic effects are so weak, they actually exert more anti-estrogenic effects on breast tissue by occupying estrogen receptors thereby blocking the effects of stronger estrogenic agents including estradiol and pesticides. PQQ has been found in all plant foods analyzed to date. Swelling of Lips: The excessive intake of milk thistle can cause the swelling of lips. The lips will be … i found some info that it affects estrogen. Might Interact With Other Drugs 8. • Promotion of apoptosis (programmed cell death) in breast cancer cells. Some women find this helpful for symptoms like hot flashes and insomnia. Milk Thistle Protects Your Liver. The most comprehensive and authoritative evaluation on the safety of milk thistle extract was conducted by the National Toxicology Program of the United States Department of Health and Human Services. As it relates to milk thistle extract (silymarin), there are warnings out in the marketplace that women avoid milk thistle extract as it increases the risk of breast cancer and has estrogenic effects. What Are the Side Effects of Using Breast Enlargement Pills? Sure enough: in one recent study , an herbal conglomerate featuring milk thistle as one of the active participants actually increased estrogen metabolism, effectively reducing the amount of active estrogen by speeding up its clearance from the body. Supplements containing extracts of the silymarin-phosphatidylcholine compound are generally limited to 200 to 400 milligrams a day, while herbal tinctures and liquid extracts of milk thistle often include recommended dosages on their labels according to the level of dilution. 2015 Jun;41(6):540-6. Try: tincture or capsules between 50-150 milligrams daily. Jacobs BP, Dennehy G, Ramirez J, et al. Commonly available in capsule, liquid extract and tincture form, milk thistle has a variety of estrogen-like properties that may worsen certain health conditions sensitive to estrogen, such as endometriosis. Consult your doctor. • Stimulating the formation of new liver cells to replaced those that are damaged. Side effects include stomach upset, allergic reaction, and diarrhea. 1. Milk thistle might help the body break down estrogen pills to get rid of them. Milk Thistle is known to have mild phytoestrogenic properties, but it also is incredibly liver protective which renders it useful for many women dealing with estrogen-dominant fertility health issues (details about which I share in a few other comments on this article). Might Lower Blood Sugar Way Too Much 6. Everything functions better when the heart works as it should. Milk thistle is mainly a plant with long spiny leaves. Extracts from parts of the plant other than the seeds may increase estrogen levels in the body. So what did the results show? Connolly holds advanced degrees from the University of North Carolina, Asheville and the University of Virginia. Some studies have linked milk thistle compounds called silymarins with antioxidant and anti-inflammatory effects on the liver and other organs. Learn more about PQQ with the following Q&A. Cancer Lett. Although milk thistle may theoretically improve estrogen levels in the body, few studies have been performed on its effectiveness. These foods contain 2–3 mcg of PQQ per 100 grams. Copyright © 2021 Dr. Michael Murray     | Website by Gill Brooks | Privacy Policy | Terms and Conditions, Facehttp://www.facebook.com/pages/Doctor-Murray/189599547723266?sk=wallbook, Twitterhttp://twitter.com/#!/DrMichaelMurray. Not at all, in fact telling women to avoid milk thistle extract is doing them a disservice. On the flip side, many phytoestrogens are able to act on bone metabolism in a very positive manner. 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